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Cancer Invest. 2010 Nov;28(9):963-8. doi: 10.3109/07357907.2010.496759.

Population-based estimate of the prevalence of HER-2 positive breast cancer tumors for early stage patients in the US.

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  • 1Surveillance Research Program, National Cancer Institute, Bethesda, Maryland, USA.


The goal of this study was to estimate prevalence of HER-2 positive tumors in a population-based sample of 1026 women diagnosed in 2005 with early stage breast cancer. We modeled the relationship between patient and tumor characteristics and HER-2. HER-2 positive estimates were 19% for women aged ≤ 49 years and 15% aged ≥ 50 years. HER-2 varied by tumor grade and size in women aged ≤ 49 years but was not significant in multivariate analysis. Tumor grade and race were associated with HER-2 for women aged ≥ 50 years after controlling for other variables. HER-2 varies by age and by race and tumor in older women.

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