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    Cancer Invest. 2010 Nov;28(9):963-8. doi: 10.3109/07357907.2010.496759.

    Population-based estimate of the prevalence of HER-2 positive breast cancer tumors for early stage patients in the US.

    Cronin KA, Harlan LC, Dodd KW, Abrams JS, Ballard-Barbash R.

    Source

    Surveillance Research Program, National Cancer Institute, Bethesda, Maryland, USA. cronink@mail.nih.gov

    Abstract

    The goal of this study was to estimate prevalence of HER-2 positive tumors in a population-based sample of 1026 women diagnosed in 2005 with early stage breast cancer. We modeled the relationship between patient and tumor characteristics and HER-2. HER-2 positive estimates were 19% for women aged ≤ 49 years and 15% aged ≥ 50 years. HER-2 varied by tumor grade and size in women aged ≤ 49 years but was not significant in multivariate analysis. Tumor grade and race were associated with HER-2 for women aged ≥ 50 years after controlling for other variables. HER-2 varies by age and by race and tumor in older women.

    PMID:
    20690807
    [PubMed - indexed for MEDLINE]

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