Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Oral Sci. 2010 Mar;2(1):45-52. doi: 10.4248/IJOS10011.

Cytomorphological analysis of keratinocytes in oral smears from tobacco users and oral squamous cell carcinoma lesions--a histochemical approach.

Author information

  • 1Jaipur Dental College, Jaipur Highway, Jaipur, India.

Abstract

AIM:

To analyse the cytomorphological features of keratinocytes in smears obtained from the oral mucosa of tobacco users and from oral squamous cell carcinoma lesions.

METHODOLOGY:

Oral smears were obtained from clinically, normal appearing mucosa of oral squamous cell carcinoma patients (n=20) and from the mucosa of smokers (n=20), and apparently healthy individuals (n=20) were used as controls. The smears were histochemically stained and cytomorphological assessment of the keratinocytes was carried out. One-way ANOVA (Analysis of Variance) was used for comparing the parameters among multiple groups and Tukey-HSD test was used to compare the mean values between groups.

RESULTS:

The mean nuclear area of keratinocytes from the mucosa of tobacco users was 46 +/- 2.57 and that of the oral squamous cell carcinoma lesion was 81.54 +/- 4.31. While there was a significant (P = 0.001) reduction in the cellular area of keratinocytes from oral squamous cell carcinoma lesion when compared with those from oral smears of tobacco users.

CONCLUSION:

Cytomorphometric analysis of keratinocytes can serve as a useful adjunct in the early diagnosis of oral squamous cell carcinomas.

PMID:
20690418
[PubMed - indexed for MEDLINE]
PMCID:
PMC3475591
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk