Acta Otolaryngol Suppl. 1991;479:24-8.

Histamine in the treatment of vertigo.

Source

St. Jans-Gasthuis, Weert, The Netherlands.

Abstract

The vasodilating properties of histamine were the basis for histamine treatment of episodic vertigo and other inner ear dysfunctions. The successes obtained led to the development of betahistine: an orally active histamine analogue; its general pharmacology resembles that of histamine. Animal pharmacology experiments proved that betahistine increases cerebral blood flow and probably also affects vestibular neurons. From clinical studies, it appears that betahistine is an effective agent for the symptomatic treatment of Meniere's syndrome. Efficacy has also been shown in the treatment of patients suffering from paroxysmal vertigo.

PMID:: 2068937; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

HISTAMINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Treatment of acute vestibular vertigo. [Acta Otolaryngol Suppl. 1991]
Treatment of acute vestibular vertigo.
Aantaa E. Acta Otolaryngol Suppl. 1991; 479:44-7.
Review Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action. [CNS Drugs. 2001]
Review Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action.
Lacour M, Sterkers O. CNS Drugs. 2001; 15(11):853-70.
Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches. [Acta Otorhinolaryngol Ital. 2001]
Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches.
Mira E. Acta Otorhinolaryngol Ital. 2001 Jun; 21(3 Suppl 66):1-7.
[Trimetazidine versus betahistine in vestibular vertigo. A double blind study]. [Ann Otolaryngol Chir Cervicofa...]
[Trimetazidine versus betahistine in vestibular vertigo. A double blind study].
Kluyskens P, Lambert P, D'Hooge D. Ann Otolaryngol Chir Cervicofac. 1990; 107 Suppl 1:11-9.
Review Betahistine: what's new on the agenda? [Expert Opin Investig Drugs. 2008]
Review Betahistine: what's new on the agenda?
Barak N. Expert Opin Investig Drugs. 2008 May; 17(5):795-804.

See reviews... See all...

Cited by 2 PubMed Central articles

Betahistine in the treatment of Ménière's disease. [Neuropsychiatr Dis Treat. 2007]
Betahistine in the treatment of Ménière's disease.
Lacour M, van de Heyning PH, Novotny M, Tighilet B. Neuropsychiatr Dis Treat. 2007 Aug; 3(4):429-40.
Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats. [J Physiol. 2006]
Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats.
Bergquist F, Ruthven A, Ludwig M, Dutia MB. J Physiol. 2006 Dec 15; 577(Pt 3):857-68. Epub 2006 Oct 12.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Histamine in the treatment of vertigo.
Histamine in the treatment of vertigo.
Acta Otolaryngol Suppl. 1991 ;479:24-8.

PubMed
The Korean prediction model for adolescents' future smoking intentions.
The Korean prediction model for adolescents' future smoking intentions.
J Prev Med Public Health. 2010 Jul ;43(4):283-91.

PubMed
Developmental biology. Which parental gene gets the upper hand?
Developmental biology. Which parental gene gets the upper hand?
Science. 2010 Aug 6 ;329(5992):636-7.

PubMed
Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to c...
Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review.
Chest. 2011 Jan ;139(1):28-35. Epub 2010 Aug 5 .

PubMed
The emergence of translational epidemiology: from scientific discovery to popula...
The emergence of translational epidemiology: from scientific discovery to population health impact.
Am J Epidemiol. 2010 Sep 1 ;172(5):517-24. Epub 2010 Aug 5 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: