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J Clin Microbiol. 2010 Oct;48(10):3738-41. doi: 10.1128/JCM.00722-10. Epub 2010 Aug 4.

Is repeat PCR needed for diagnosis of Clostridium difficile infection?

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  • 1Stanford University School of Medicine, Department of Pathology, Palo Alto, CA 94304, USA. rluo2@stanford.edu

Abstract

Patients with diarrhea, defined as loose or watery stool, and two or more Clostridium difficile tcdB PCR tests within 14 days of each other were investigated. Repeat PCR for 293 patients with a prior negative result yielded negative results in 396 (97.5%) of 406 tests. Ten new positives were detected, including one false positive. Repeat PCR within 7 days appears rarely useful, except for patients with evidence of a new infection.

PMID:
20686078
[PubMed - indexed for MEDLINE]
PMCID:
PMC2953130
Free PMC Article
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