J Clin Microbiol. 2010 Oct;48(10):3813-6. Epub 2010 Aug 4.

Microevolution of Mycobacterium tuberculosis in a tuberculosis patient.

Al-Hajoj SA, Akkerman O, Parwati I, al-Gamdi S, Rahim Z, van Soolingen D, van Ingen J, Supply P, van der Zanden AG.

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Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. hajoj@kfshrc.edu.sa

Abstract

Five Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection.

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