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J Clin Endocrinol Metab. 2010 Nov;95(11):5069-73. doi: 10.1210/jc.2010-0610. Epub 2010 Aug 4.

The 25(OH)D/PTH threshold in black women.

Author information

  • 1Bone Mineral Research Center, Winthrop-University Hospital, Mineola, New York 11501, USA. jaloia@winthrop.org

Abstract

CONTEXT:

Black women have lower 25-hydroxyvitamin D [25(OH)D] and higher PTH than white women. Recent evidence implicates PTH in adverse cardiovascular outcomes.

OBJECTIVE:

The objective of the study was to determine whether PTH increases at lower 25(OH)D levels (the threshold) in black compared with white women.

DESIGN:

Healthy black and white women, aged 20-80 yr were recruited to participate in a cross-sectional study of body-composition in black and white women. Measurement of serum 25(OH)D and PTH were carried out.

SETTING:

The study was a convenience sample recruited from a community setting.

PATIENTS:

Healthy black and white women were recruited by advertising and a direct mail campaign in a comparative study of body composition. Age ranged from 20-to 80 yr. There were 148 black and 129 white premenopausal participants and 87 black and 139 white postmenopausal participants.

MAIN OUTCOME:

The main outcome was to determine whether the threshold for 25(OH)D/PTH differs in black and white women.

RESULTS:

A threshold of 37 nmol/liter (95% confidence interval 35-40) was found for black and 59 nmol/liter (95% confidence interval 56-63) for white women. These two values were significantly different (P < 0.001).

CONCLUSIONS:

Black women have an increase in serum PTH at a lower 25(OH)D level than white women. Negative health outcomes of higher PTH should be investigated in black women.

PMID:
20685862
[PubMed - indexed for MEDLINE]
PMCID:
PMC2968726
Free PMC Article
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