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Psychiatry Res. 2010 Sep 30;183(3):218-24. doi: 10.1016/j.pscychresns.2009.06.004. Epub 2010 Aug 3.

Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence.

Author information

  • 1Department of Psychiatry, UCLA, Los Angeles, CA 90095, USA. abrody@ucla.edu

Abstract

The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. Forty-three otherwise healthy adult cigarette smokers (10 to 40 cigarettes per day) were treated with either practical group counseling (PGC) psychotherapy (n=14), bupropion HCl (n=14), or matching pill placebo (n=15) (random assignment) for 8 weeks. Before and after treatment, each subject underwent a bolus-plus-continuous-infusion (11)C-raclopride positron emission tomography (PET) scanning session, during which he or she smoked a regular cigarette. The PET scanning outcome measure of interest was percent change in smoking-induced (11)C-raclopride binding potential (BP(ND)) in the ventral caudate/nucleus accumbens (VCD/NAc), as an indirect measure of DA release. Although the entire study sample had a smaller mean smoking-induced reduction in VCD/NAc BP(ND) after treatment (compared to before treatment), this change was highly correlated with smaller total cigarette puff volumes (and not other treatment variables). These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type.

Published by Elsevier Ireland Ltd.

PMID:
20682457
[PubMed - indexed for MEDLINE]
PMCID:
PMC2947623
Free PMC Article
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