BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors

J Clin Oncol. 2010 Oct 10;28(29):e563-4; author reply e565-6. doi: 10.1200/JCO.2010.30.1010. Epub 2010 Aug 2.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • BRCA1 Protein / genetics
  • BRCA2 Protein / genetics
  • CpG Islands / genetics*
  • DNA Methylation*
  • Female
  • Germ-Line Mutation
  • Humans
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / enzymology
  • Ovarian Neoplasms / genetics
  • Phthalazines / therapeutic use*
  • Piperazines / therapeutic use*
  • Poly(ADP-ribose) Polymerase Inhibitors*
  • Poly(ADP-ribose) Polymerases / genetics
  • Prognosis
  • Treatment Outcome

Substances

  • BRCA1 Protein
  • BRCA2 Protein
  • Phthalazines
  • Piperazines
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Poly(ADP-ribose) Polymerases
  • olaparib