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Genes Dev. 2010 Aug 1;24(15):1580-9. doi: 10.1101/gad.1941710.

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.

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  • 1Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA.

Erratum in

  • Genes Dev. 2010 Sep 15;24(18):2105.


Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic pathways independent of p53. Although its role as an oncogene via suppression of p53 function remains clear, growing evidence argues for p53-independent effects, as well as the remarkable possibility that Mdm2 has tumor suppressor functions in the appropriate context. Hence, Mdm2 is proving to be a key player in human cancer in its own right, and thus an important target for therapeutic intervention.

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