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J Neuroimmunol. 2010 Sep 14;226(1-2):172-6. doi: 10.1016/j.jneuroim.2010.07.006. Epub 2010 Aug 1.

Two HLA class I genes independently associated with multiple sclerosis.

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  • 1Karolinska Institutet, Department of Clinical Neuroscience, CMM L8:00, SE-17176 Stockholm, Sweden. jenny.link@ki.se

Abstract

OBJECTIVE:

The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation.

METHODS:

1529 MS patients and 1814 controls from Sweden and Norway were genotyped for HLA-DRB1, HLA-A, and HLA-C. Simultaneous analysis of all alleles while adjusting for confounding was achieved using logistic regression.

RESULTS:

We observed independent effects of all three genes. We confirm the HLA-A*02 (OR=0.73, p=9.2 x 10(-4)) association and report a novel effect of HLA-C*08 (OR=1.85, p=0.0093).

CONCLUSIONS:

The HLA class I region contains two factors modulating MS risk, characterized by independent associations with HLA-A and HLA-C.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
20678810
[PubMed - indexed for MEDLINE]
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