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J Drugs Dermatol. 2010 Jul;9(7):844-50.

Familial pityriasis rubra pilaris: report of a family and therapeutic response to etanercept.

Author information

  • 1Department of Dermatology and Cutaneous Surgery, University of South Florida,Tampa, FL 33612, USA.

Abstract

Pityriasis rubra pilaris (PRP) is an uncommon dermatosis of unknown etiology. The familial subtype is rare and usually presents as type V PRP. It is generally inherited in an autosomal dominant fashion with variable expression. Other forms of inheritance, such as autosomal recessive and X-linked, have also been reported. The use of etanercept in treating resistant forms of PRP is promising given reports of its success in a few cases. Herein, the authors report two cases of PRP arising in a mother and son and review the rare familial subtype of this disease. In addition, a successful therapeutic trial of etanercept was initiated in the mother based on case reports of its efficacy in other patients with PRP.

PMID:
20677542
[PubMed - indexed for MEDLINE]
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