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Nat Neurosci. 2010 Sep;13(9):1050-2. doi: 10.1038/nn.2604. Epub 2010 Aug 1.

Calcium action potentials in hair cells pattern auditory neuron activity before hearing onset.

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  • 1The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Abstract

We found rat central auditory neurons to fire action potentials in a precise sequence of mini-bursts before the age of hearing onset. This stereotyped pattern was initiated by hair cells in the cochlea, which trigger brief bursts of action potentials in auditory neurons each time they fire a Ca2+ spike. By generating theta-like activity, hair cells may limit the influence of synaptic depression in developing auditory circuits and promote consolidation of synapses.

PMID:
20676105
[PubMed - indexed for MEDLINE]
PMCID:
PMC2928883
Free PMC Article
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