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J Affect Disord. 2010 Nov;126(3):430-5. doi: 10.1016/j.jad.2010.07.006. Epub 2010 Aug 1.

Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorder.

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  • 1Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Abstract

BACKGROUNDS:

To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD).

METHODS:

We recruited 117 MDD patients who were randomized to fluoxetine or venlafaxine treatment and 106 controls. The association between genotypes and percentage changes in the Hamilton Rating Scale for Depression (HAM-D) scores over time was analyzed by repeated-measures ANOVA. The antidepressants were included in the model as covariates.

RESULTS:

The frequency of the BDNF Val66Met polymorphisms was not significantly different between patient and control groups. Significantly changes in HAM-D scores were noted after 2 and 4 weeks of venlafaxine treatment among different genotypes.

CONCLUSIONS:

Results suggest antidepressants acting through different mechanisms may affect the BDNF Val66Met polymorphism differently.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
20674983
[PubMed - indexed for MEDLINE]
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