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    Bioorg Med Chem Lett. 2010 Sep 1;20(17):5170-4. Epub 2010 Jul 8.

    Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

    Belanger DB, Curran PJ, Hruza A, Voigt J, Meng Z, Mandal AK, Siddiqui MA, Basso AD, Gray K.

    Source

    Department of Chemistry, Merck Research Laboratories, Cambridge, MA 02141, USA. david.belanger@merck.com

    Abstract

    The synthesis and structure-activity relationships (SAR) of novel, potent imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors are described. The X-ray crystal structure of imidazo[1,2-a]pyrazine Aurora inhibitor 1j is disclosed. Compound 10i was identified as lead compound with a promising overall profile.

    Copyright 2010 Elsevier Ltd. All rights reserved.

    PMID:
    20674350
    [PubMed - indexed for MEDLINE]

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