Bioorg Med Chem Lett. 2010 Sep 1;20(17):5232-6. Epub 2010 Jul 29.

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents.

Kamal A, Reddy JS, Ramaiah MJ, Bharathi EV, Dastagiri D, Reddy MK, Pushpavalli SN, Pal-Bhadra M.

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Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India. ahmedkamal@iict.res.in

Abstract

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.

PMID:: 20673627; [PubMed - indexed for MEDLINE]

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