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Mol Cell. 2010 Jul 30;39(2):162-4. doi: 10.1016/j.molcel.2010.07.007.

Repair scaffolding reaches new heights at blocked replication forks.

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  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158-9001, USA.


In this issue of Molecular Cell, Ohouo et al. (2010) show that Mec1 (hATR) promotes the association of Slx4 and Rtt107 with Dpb11 (hTopBP1) in response to MMS-induced DNA alkylation, suggesting that Slx4 and Rtt107 might coordinate repair factors specifically at damaged replication forks.

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