The effect of medication use on urinary incontinence in community-dwelling elderly women

J Am Geriatr Soc. 2010 Sep;58(9):1715-20. doi: 10.1111/j.1532-5415.2010.03006.x.

Abstract

Objectives: To evaluate whether use of certain medications with potential urological effects is associated with development of incident urinary incontinence in community-resident older women.

Design: Longitudinal cohort study.

Setting: Pittsburgh, PA, and Memphis, TN.

Participants: Nine hundred fifty-nine healthy black and white women aged 65 and older enrolled in the Health, Aging and Body Composition Study without baseline (Year 1) self-reported urinary incontinence.

Measurements: Use of alpha blockers, anticholinergics, central nervous system medications (opioids, benzodiazepines, antidepressants, antipsychotics), diuretics (thiazide, loop, potassium sparing), and estrogen (all dosage forms) was determined during Year 3 interviews. Self-reported incident (≥ weekly) incontinence in during the previous 12 months was assessed at Year 4 interviews.

Results: Overall, 20.5% of these women reported incident incontinence at Year 4 (3 years from baseline). The most common medication used with potential urological activity was a thiazide diuretic (24.3%), followed by estrogen (22.2%); alpha blockers were the least commonly used (2.3%). Multivariable logistic regression analyses revealed that current users of alpha blockers (adjusted odds ratio (AOR)=4.98, 95% confidence interval (CI)=1.96-12.64) and estrogen (AOR=1.60, 95% CI=1.08-2.36) had a greater risk of urinary incontinence than nonusers. There was no greater risk (P>.05) of urinary incontinence with the current use of anticholinergics, central nervous system medications, or diuretics. No statistically significant race-by-medication use interactions were found (all P>.05).

Conclusion: These results corroborate earlier reports that, in elderly women, use of alpha blockers or estrogens is associated with risk of self-reported incident urinary incontinence.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged
  • Cardiovascular Agents / adverse effects*
  • Cardiovascular Diseases / drug therapy*
  • Central Nervous System Agents / adverse effects*
  • Central Nervous System Diseases / drug therapy*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • Time Factors
  • United States / epidemiology
  • Urinary Incontinence / chemically induced
  • Urinary Incontinence / epidemiology*
  • Urinary Incontinence / physiopathology
  • Urodynamics / drug effects*

Substances

  • Cardiovascular Agents
  • Central Nervous System Agents