J Rheumatol. 1991 Apr;18(4):530-4.

Procainamide inhibits DNA methyltransferase in a human T cell line.

Scheinbart LS, Johnson MA, Gross LA, Edelstein SR, Richardson BC.

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Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0531.

Abstract

Procainamide, a widely used antiarrythmic, causes DNA hypomethylation in the human T cell line Jurkat, but the mechanism is unknown. We report that procainamide inhibits the DNA methyltransferase catalyzed transfer of methyl groups from S-adenosylmethionine to DNA, but has no effect on other known regulators of DNA methylation. Our results suggest that procainamide could inhibit cellular DNA methylation by inhibiting DNA methyltransferase activity.

PMID:: 2066944; [PubMed - indexed for MEDLINE]

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Procainamide inhibits DNA methyltransferase in a human T cell line.

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