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Audiol Neurootol. 2011;16(3):137-44. doi: 10.1159/000314757. Epub 2010 Jul 29.

Pre-operative intravenous dexamethasone prevents auditory threshold shift in a guinea pig model of cochlear implantation.

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  • 1Department of Otolaryngology, University of Melbourne, East Melbourne, Vic., Australia.

Abstract

AIM:

To protect hearing during cochlear implantation with systemic administration of dexamethasone.

METHODS:

Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2-32 kHz) were estimated between pre- and 4-week-postoperative levels.

RESULTS:

ABR threshold shifts (8-32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group.

CONCLUSIONS:

A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.

Copyright © 2010 S. Karger AG, Basel.

PMID:
20668374
[PubMed - indexed for MEDLINE]
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