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    Bioorg Med Chem. 2010 Aug 15;18(16):5845-54. Epub 2010 Jul 1.

    Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis.

    Kuroyanagi J, Kanai K, Sugimoto Y, Fujisawa T, Morita C, Suzuki T, Kawakami K, Takemura M.

    Source

    Lead Discovery & Optimization Research Laboratories II, Daiichi Sankyo Co., Ltd, Edogawa-ku, Tokyo 134-8630, Japan. kuroyanagi.junichi.d5@daiichisankyo.co.jp

    Abstract

    Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of beta-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species.

    Copyright 2010 Elsevier Ltd. All rights reserved.

    PMID:
    20667743
    [PubMed - indexed for MEDLINE]

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