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Trends Microbiol. 2010 Oct;18(10):448-54. doi: 10.1016/j.tim.2010.07.002. Epub 2010 Jul 29.

Interkingdom signaling between pathogenic bacteria and Caenorhabditis elegans.

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  • 1Department of Biology, Reed College, Portland, OR 97202, USA.


Investigators have recently turned to the soil nematode Caenorhabditis elegans as a small animal infection model to study infectious disease. To extrapolate findings concerning bacterial pathogenesis from non-mammals to mammals, virulence factors should be conserved in function, independent of the infection model. Emerging from these studies is the observation that bacterial virulence regulatory networks function in a conserved manner across multiple hosts, including nematodes, mice and plants. Several regulatory networks have been implicated in nematode innate immune function and are being exploited in the C. elegans infection model to develop novel chemical therapies against bacterial pathogens.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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