Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Clin Periodontol. 2010 Sep;37(9):805-11. doi: 10.1111/j.1600-051X.2010.01605.x. Epub 2010 Jul 21.

Association of salivary lysozyme and C-reactive protein with metabolic syndrome.

Author information

  • 1Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland.

Abstract

INTRODUCTION:

Salivary lysozyme (SLZ) is a proteolytic enzyme secreted by oral leucocytes and contains a domain that has an affinity to advanced glycation end products (AGE). Thus, we hypothesized that SLZ would be associated with metabolic syndrome (metS), a pro-inflammatory state.

METHODS:

Utilizing cross-sectional data from 250 coronary artery disease (CAD) and 250 non-CAD patients, the association of SLZ with metS was tested by logistic regression analyses controlling for age, sex, smoking, total cholesterol and C-reactive protein (CRP) levels. The analyses were stratified by CAD status to control for the possible effects of CAD.

RESULTS:

MetS was found in 122 persons. The adjusted odds ratio (OR) for metS associated with the highest quartile of SLZ was 1.95 with 95% confidence interval (CI) 1.20-3.12, p-value=0.007, compared with the lower three quartiles combined. Among the 40 subjects with metS but without CAD, the OR was 1.63 (CI: 0.64-4.15, p=0.31), whereas in the CAD group, SLZ was significantly associated with metS [OR=1.96 (1.09-3.52), p=0.02]. In both subgroups, CRP was not significantly associated with metS.

CONCLUSION:

SLZ was significantly associated with metS (OR=1.95) independent of CRP level. Future longitudinal research is warranted.

PMID:
20666873
[PubMed - indexed for MEDLINE]
PMCID:
PMC2923268
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk