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Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21.

Toll-like receptor 4 and hepatic fibrogenesis.

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  • 1Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.


Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.

Copyright Thieme Medical Publishers.

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