Format

Send to:

Choose Destination
See comment in PubMed Commons below
Gut. 2010 Sep;59(9):1279-87. doi: 10.1136/gut.2009.192732. Epub 2010 Jul 26.

Abnormalities of lipid metabolism in hepatitis C virus infection.

Author information

  • 1Divisions of Clinical Pathology and of Gastroenterology and Hepatology, University Hospital, rue Gabrielle-Perret-Gentil 4, 1211 Genève 4, Switzerland. francesco.negro@hcuge.ch

Abstract

Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to modulate (and, indeed, are essential to) the HCV life cycle; and (3) an occasionally severe accumulation of triglycerides is found in a distinct subgroup of patients in the form of hepatic steatosis. As a result, lipid metabolism is overall altered, conferring an idiosyncratic profile to HCV infection. The scope of this review is to discuss these aspects, focusing on both their molecular mechanisms and their clinical consequences.

PMID:
20660700
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk