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Antimicrob Agents Chemother. 2010 Oct;54(10):4474-5. doi: 10.1128/AAC.00697-10. Epub 2010 Jul 26.

In vivo efficacy of anidulafungin against mature Candida albicans biofilms in a novel rat model of catheter-associated Candidiasis.

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  • 1Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium.

Abstract

The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.

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