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Chem Biol. 2010 Jul 30;17(7):677-8. doi: 10.1016/j.chembiol.2010.07.001.

No taste for methyl: methylation sensitive proteolysis in drug screening.

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  • 1Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit├Ąt Freiburg, Albertstr. 25, 79104 Freiburg, Germany.


Methyltransferases and demethylases are emerging targets for epigenetic therapy. Wigle et al. (2010) present a new assay for the enzyme inhibition of methyltransferases and demethylases based on selective enzymatic cleavage of unmethylated versus methylated peptides and their subsequent electrophoretic separation.

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