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Int J Cancer. 2011 May 15;128(10):2274-83. doi: 10.1002/ijc.25575.

MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.

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  • 1Department of Medical Genetics, China Medical University, Shenyang, China.

Abstract

Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal formation. This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene, BCL3. Furthermore, expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development.

Copyright © 2010 UICC.

PMID:
20658525
[PubMed - indexed for MEDLINE]
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