Abstract
The strain-promoted "double-click" (SPDC) reaction using Sondheimer diyne, a novel convergent method conjugating three molecules spontaneously, has enabled us to readily modify an azido-biomolecule with a small reporter azido-molecule.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Azides / chemistry*
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Carbohydrates / chemistry*
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Cell Line
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Click Chemistry / methods*
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Computer Simulation
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Crystallography, X-Ray
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Fluorescent Dyes / chemistry*
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Humans
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Lipids / chemistry*
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Models, Molecular
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Molecular Structure
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Nucleotides / chemistry*
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Proteins / chemistry*
Substances
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Azides
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Carbohydrates
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Fluorescent Dyes
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Lipids
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Nucleotides
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Proteins