Send to:

Choose Destination
See comment in PubMed Commons below
Blood. 2010 Oct 28;116(17):3140-6. doi: 10.1182/blood-2010-05-280883. Epub 2010 Jul 23.

Systematic review and meta-analysis methodology.

Author information

  • 1Department of Haematology, Worcestershire Royal Hospital, Worcester, United Kingdom.


Systematic reviews and meta-analyses are being increasingly used to summarize medical literature and identify areas in which research is needed. Systematic reviews limit bias with the use of a reproducible scientific process to search the literature and evaluate the quality of the individual studies. If possible the results are statistically combined into a meta-analysis in which the data are weighted and pooled to produce an estimate of effect. This article aims to provide the reader with a practical overview of systematic review and meta-analysis methodology, with a focus on the process of performing a review and the related issues at each step.

[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk