Fragment-based discovery and optimizati... [Bioorg Med Chem Lett. 2010] - PubMed

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Fragment-based discovery of BACE1 inhibitors using functional assays. [Biochemistry. 2009]
Fragment-based discovery of BACE1 inhibitors using functional assays.
Godemann R, Madden J, Krämer J, Smith M, Fritz U, Hesterkamp T, Barker J, Höppner S, Hallett D, Cesura A, et al. Biochemistry. 2009 Nov 17; 48(45):10743-51.
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors. [ChemMedChem. 2008]
alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors.
Asso V, Ghilardi E, Bertini S, Digiacomo M, Granchi C, Minutolo F, Rapposelli S, Bortolato A, Moro S, Macchia M. ChemMedChem. 2008 Oct; 3(10):1530-4.
Review Aspartic proteases in drug discovery. [Curr Pharm Des. 2007]
Review Aspartic proteases in drug discovery.
Eder J, Hommel U, Cumin F, Martoglio B, Gerhartz B. Curr Pharm Des. 2007; 13(3):271-85.
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors. [Bioorg Med Chem Lett. 2007]
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Lindsley SR, Moore KP, Rajapakse HA, Selnick HG, Young MB, Zhu H, Munshi S, Kuo L, McGaughey GB, Colussi D, et al. Bioorg Med Chem Lett. 2007 Jul 15; 17(14):4057-61. Epub 2007 Apr 27.
Review Inhibition of BACE1 for therapeutic use in Alzheimer's disease. [Int J Clin Exp Pathol. 2010]
Review Inhibition of BACE1 for therapeutic use in Alzheimer's disease.
Luo X, Yan R. Int J Clin Exp Pathol. 2010 Jul 8; 3(6):618-28. Epub 2010 Jul 8.

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Fragment-based discovery and optimization of BACE1 inhibitors.
Fragment-based discovery and optimization of BACE1 inhibitors.
Bioorg Med Chem Lett. 2010 Sep 1 ;20(17):5329-33. Epub 2010 Jun 27 .

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