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J Proteomics. 2010 Nov 10;73(12):2365-9. doi: 10.1016/j.jprot.2010.07.009. Epub 2010 Jul 23.

A surface protein of Streptococcus suis serotype 2 identified by proteomics protects mice against infection.

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  • 1The Elie Metchnikoff Department, University of Messina, Messina, Italy.


Streptococcus suis serotype 2 is a major Gram-positive swine pathogen, causing also zoonoses. We describe here the immunoprotective activity in an in vivo animal model of a serotype-2 cell wall protein, designated Sat, which was identified by a previously validated proteomics approach consisting of the protease digestion of live bacteria and the selective recovery of exposed domains, followed by LC/MS/MS analysis. Increased survival rate (80%) and decreased bacterial burden were observed in mice immunized with a recombinant Sat fragment, suggesting that this protein is a potential vaccine candidate against serotype-2 infection.

Copyright © 2010 Elsevier B.V. All rights reserved.

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