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    Mol Cell Endocrinol. 2010 Oct 26;328(1-2):104-8. Epub 2010 Jul 23.

    ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity.

    Yung Y, Maman E, Konopnicki S, Cohen B, Brengauz M, Lojkin I, Dal Canto M, Fadini R, Dor J, Hourvitz A.

    Source

    IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Centre, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. yuval.yung@sheba.health.gov.il

    Abstract

    ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice show impaired follicular development and ovulatory processes. However, ADAMTS-1 expression and function in human normal ovulation and folliculogenesis have not yet been determined. The objective of this study is to study the expression patterns of ADAMTS-1 in human granulosa cells (GCs) obtained from follicles aspirated during in vitro maturation (IVM) and in vitro fertilization (IVF) procedures. We found that ADAMTS-1 expression is a luteinizing hormone/human chorionic gonadotropin (LH/hCG)-induced gene whose expression in the mural GCs directly correlated with antral follicular growth. Interestingly, we were able to show a significant correlation between ADAMTS-1 expression in cumulus cells and the fertilization capacity of the related oocyte. In conclusion, human ADAMTS-1 is an ovulatory gene and its expression is LH/hCG- and follicle-size dependent. The correlation between its expression in cumulus GCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function.

    Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

    PMID:
    20655981
    [PubMed - indexed for MEDLINE]

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