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Virus Res. 2010 Dec;154(1-2):98-103. doi: 10.1016/j.virusres.2010.07.018. Epub 2010 Jul 23.

A brief review of CD163 and its role in PRRSV infection.

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  • 1Global Biologics Research, Pfizer Animal Health, 333 Portage Street, Kalamazoo, MI 49007, USA. jenny.welch@pfizer.com

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) infects fully differentiated cells of the monocyte/macrophage lineage. Recently, CD163 was shown to be a cellular receptor capable of mediating infection of otherwise PRRSV non-permissive cell lines. CD163 is a macrophage differentiation antigen belonging to the scavenger receptor cysteine-rich (SRCR) family of membrane proteins. We provide a brief review of current knowledge regarding CD163 in relation to PRRSV infection, and propose a structure-based prediction of amino acid sequences involved in PRRSV interaction.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
20655964
[PubMed - indexed for MEDLINE]
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