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J Neuroimmunol. 2010 Oct 8;227(1-2):101-10. doi: 10.1016/j.jneuroim.2010.06.020. Epub 2010 Jul 24.

Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.

Author information

  • 1Neuroimmunology Laboratory, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Abstract

Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals. Enhanced microglial cell activation, determined by MHC class II up-regulation, overexpression of CXCL2, and elevated P-selectin mRNA levels were observed. In vivo blocking of CXCL2 attenuated neutrophil infiltration and significantly improved the outcome of infection. Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains.

Copyright © 2010 Elsevier B.V. All rights reserved.

PMID:
20655600
[PubMed - indexed for MEDLINE]
PMCID:
PMC2942961
Free PMC Article

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