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Acta Biotheor. 2010 Dec;58(4):369-80. doi: 10.1007/s10441-010-9110-0. Epub 2010 Jul 23.

Modeling the cardiovascular-respiratory control system: data, model analysis, and parameter estimation.

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  • 1Institute for Mathematics and Scientific Computing, University of Graz, Heinrichsstrasse 36, 8010 Graz, Austria.


Several key areas in modeling the cardiovascular and respiratory control systems are reviewed and examples are given which reflect the research state of the art in these areas. Attention is given to the interrelated issues of data collection, experimental design, and model application including model development and analysis. Examples are given of current clinical problems which can be examined via modeling, and important issues related to model adaptation to the clinical setting.

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