Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Tryptophan Res. 2009 Mar 23;2:45-60.

L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications.

Author information

  • 1Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, University of Texas Health Science Center at San Antonio, U.S.A.

Abstract

An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in protein synthesis and a number of other metabolic functions. With emphasis on L-tryptophan's role in synthesis of brain serotonin, details are provided on the research uses of L-tryptophan, particularly L-tryptophan depletion, and on clinical trials that have been conducted using L-tryptophan supplementation. The ability to change the rates of serotonin synthesis in the brain by manipulating concentrations of serum tryptophan is the foundation of much research. As the sole precursor of serotonin, experimental research has shown that L-tryptophan's role in brain serotonin synthesis is an important factor involved in mood, behavior, and cognition. Furthermore, clinical trials have provided some initial evidence of L-tryptophan's efficacy for treatment of psychiatric disorders, particularly when used in combination with other therapeutic agents.

PMID:
20651948
[PubMed]
PMCID:
PMC2908021
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Libertas Academica Icon for PubMed Central
    Loading ...
    Write to the Help Desk