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Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.
Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ.
J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22.
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OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.
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