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[11C]Triphenylmethylphosphonium.

Authors

Leung K.

Source

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2006 Sep 21 [updated 2012 Apr 10].

Excerpt

Lipophilic cations are capable to pass through biological membranes by passive diffusion into the cytoplasm and mitochondria of cells in response to a large negative plasma- and mitochondrial- membrane potentials. 99mTc-2-methoxyisobutylisonitrile (99mTc-MIBI) and 99mTc-tetrofosmin are delocalized lipophilic cations, which are rapidly taken up into cells being driven by metabolic demand and membrane potential (1-4). They are used as myocardial perfusion single photon emission computed tomography (SPECT) as well as tumor imaging agents. However, the high accumulation of technetium tracers in the lung and liver may hinder the detection of flow abnormalities in the myocardium. Triphenylmethylphosphonium is a lipophilic cation and has been used to measure membrane potentials of cells in vitro (5). [11C]Triphenylmethylphosphonium ([11C]TPMP) has been investigated as a positron emission tomography (PET) agent for myocardial and tumor imaging to provide a better temporal and spatial resolution than SPECT.

PMID:
20641815
[PubMed]
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