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3-β-(4-Iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester .

Authors

Leung K.

Source

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2008 Aug 11 [updated 2008 Sep 17].

Excerpt

Dopamine, a neurotransmitter, plays an important role in the mediation of movement, cognition, and emotion. Parkinson’s disease (PD) is associated with a loss of dopamine-containing neurons in the striatum, resulting in a loss of dopamine transporters (DAT) in the presynaptic nerve terminals (1, 2). Reduced DAT density is inversely correlated with the severity of motor dysfunction in PD patients. Several cocaine analogs have been developed for the evaluation of DAT density in the neurons of PD patients. Radiolabeled 2-β-carboxymethoxy-3-β-(4-iodophenyl)tropane (β-CIT) and N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) have been used for brain imaging (3-6). Because of the short physical half-life of 11C-labeled analogs, equilibrium conditions are difficult to achieve in positron emission tomography (PET) measurements. [123I]β-CIT was studied with single-photon emission computed tomography (SPECT), which showed slow tracer uptake kinetics (7, 8). This led to the development of 3-β-(4-iodophenyl)tropane-2-β-carboxylic acid 2-[18F]fluoroethyl ester ([18F]FE@CIT) for PET brain imaging in PD patients (9).

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