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99mTc-Hydrazinonicotinamide-epidermal growth factor.


Leung K.


Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2005 Jun 03 [updated 2012 Jan 11].


Epidermal growth factor (EGF) is a 53-amino acid cytokine (6.2 kDa) secreted by ectodermic cells, monocytes, kidneys and duodenal glands (1). EGF stimulates growth of epidermal and epithelial cells. EGF receptor (EGFR) is a transmembrane protein with an intracellular tyrosine kinase present on most cells. EGFR is overexpressed on many solid tumor cells, such as those of breast, non-small-cell lung, head and neck, and colon cancers (2-4). The high level of EGFR expression on cancer cells is associated with a poor prognosis (5-7). EGF has been labeled with 99mTc by various laboratories as a potential SPECT imaging agent for EGFR expression on cancer cells (8-11). The Ras protein is a key regulator in the signaling pathway of the EGFR. Inhibition of farnesylation of Ras in cancer cells by farnesyltransferase inhibitors (FTI) led to inhibition of tumor growth, up regulation of EGFR, and decreased internalization of EGFR (12). 99mTc-HYNIC-EGF was developed for in vivo prediction of cancer cell response to FTI (8).

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