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Nat Genet. 2010 Aug;42(8):658-60. doi: 10.1038/ng.627. Epub 2010 Jul 18.

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

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  • 1University Health Network, Toronto, Ontario, Canada.

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

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PMID:
20639880
[PubMed - indexed for MEDLINE]
PMCID:
PMC3150510
Free PMC Article

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