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Acta Haematol. 2010;124(2):86-91. doi: 10.1159/000314058. Epub 2010 Jul 15.

Hemoglobin H disease in Guangxi province, Southern China: clinical review of 357 patients.

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  • 1Department of Hematology, 303rd Hospital of PLA, Nanning, Guangxi, China.


The clinical characteristics of 357 patients with hemoglobin H (HbH) disease from the Guangxi province of Southern China were studied. One hundred and ninety-one (53.3%) patients were diagnosed with HbH-Constant Spring, 19 were diagnosed with HbH Westmead. Ten patients were shown to have coinherited HbH-Constant Spring/QS with a β-thalassemia mutation. Coinheritance of the β-thalassemia gene does not alleviate anemia (8.2 ± 2.3 vs. 7.6 ± 1.7 g/dl, p = 0.276), or influence age at diagnosis (20.2 ± 19.6 vs. 12.9 ± 11.0 years, p = 0.276). Ferritin levels were significantly higher in the group of patients with the nondeletional form of the disease (475 ± 719 vs. 249 ± 264 ng/ml, p = 0.005).

Copyright © 2010 S. Karger AG, Basel.

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