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Clin Neurophysiol. 2011 Feb;122(2):229-35. doi: 10.1016/j.clinph.2010.06.018. Epub 2010 Jul 15.

Topographical frequency dynamics within EEG and MEG sleep spindles.

Author information

  • 1Multimodal Imaging Laboratory, Department of Radiology, University of California, San Diego, CA, USA.

Abstract

OBJECTIVE:

Spindles are rhythmic bursts of 10-16 Hz activity, lasting ∼1 s, occur during normal stage 2 sleep. Spindles are slower in frontal EEG and possibly MEG. The posterior-fast EEG pattern may predominate early in the spindle, and the anterior-slow pattern late. We aimed to determine the proportion of spindles showing this spatio-spectro-temporal interaction for EEG, and whether it occurs in MEG.

METHODS:

We recorded high density EEG and MEG from seven healthy subjects during normal stage 2 sleep. High vs. low frequency (12 vs. 14 Hz) power was measured early vs. late (25th-45th vs. 55th-75th duration percentile) in 183 spindle discharges.

RESULTS:

The predicted spatio-spectro-temporal interaction was shown by 48% of EEG and 34% of MEG spindles (chance=25%). Topographically, high frequency EEG power was greatest at midline central contacts, and low frequency power at midline frontal. This frequency-specific topography was fixed over the course of the spindle.

CONCLUSIONS:

An evolution from posterior-fast to anterior-slow generators commonly occurs during spindles, and this is visible with EEG and to a lesser extent, MEG.

SIGNIFICANCE:

The spatio-spectral-temporal evolution of spindles may reflect their possible involvement in coordinating cortical activity during consolidation.

Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

PMID:
20637689
[PubMed - indexed for MEDLINE]
PMCID:
PMC2978261
Free PMC Article

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