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Ecotoxicol Environ Saf. 2010 Sep;73(6):1286-91. doi: 10.1016/j.ecoenv.2010.06.019. Epub 2010 Jul 16.

Effect of waterborne copper exposure on growth, hepatic enzymatic activities and histology in Synechogobius hasta.

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  • 1Fishery College, Huazhong Agricultural University, Wuhan 430070, China.


The present study was conducted to determine growth, hepatic enzymatic activities and histology in Synechogobius hasta exposed to waterborne copper concentrations of 0 (control), 0.15 and 0.3 mg Cu/l, respectively, for 15 days, and explore whether waterborne copper exposure could induce the fatty liver syndrome for the fish species. Growth (WG and SGR) declined, but HSI increased in S. hasta with increasing waterborne copper levels (P<0.05). Waterborne copper exposure also significantly increased lipid content and reduced protein content in both whole body and liver, and increased copper accumulation in whole body and vertebrae. Copper exposure changed hepatic enzymatic activities (SOD, CAT, SDH, PK, LDH, LPL and HL) and increased hepatic lipid peroxidation level, impaired the histological structure of the gill and liver in S. hasta. Thus, our study demonstrated for the first time that waterborne Cu exposure could induce fatty liver syndrome in fish.

Copyright (c) 2010 Elsevier Inc. All rights reserved.

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