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J Pharm Pharmacol. 2010 Jul;62(7):809-20. doi: 10.1211/jpp.62.06.0001.

Scientific evidence for Mikania laevigata and Mikania glomerata as a pharmacological tool.

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  • 1Laboratory of Biopathology and Molecular Biology, University of Uberaba, Minas Gerais 38055-500, Brazil.



Historically, the majority of new drugs have been generated from natural products as well as from compounds derived from natural products. In this context, Mikania laevigata and M. glomerata, popularly known as 'guaco', have a long history of use. Brazilian Indians have an ancient tradition of using 'guaco' for snakebites. In current herbal medicine in Brazil, 'guaco' is used as an effective natural bronchodilator, expectorant and cough suppressant employed for all types of upper respiratory problems including bronchitis, pleurisy, colds and flu, coughs and asthma.


In Brazil, this plant has been widely used, even as commercial preparations. Its medicinal properties are widely recognized, mainly in the treatment of inflammatory conditions, bronchodilator activity, anti-ulcerogenic, antiophidian as well as antibacterial and antiparasitic activity, although the efficacy of the antibacterial activity is so far controversial.


The studies on Mikania glomerata and M. laevigata have provided scientific evidence that those plants have a considerable anti-inflammatory therapeutic potential.

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