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Immunol Rev. 2010 Jul;236:151-66. doi: 10.1111/j.1600-065X.2010.00926.x.

Generation of effector CD8+ T cells and their conversion to memory T cells.

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  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.

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