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Psychiatry Res. 2010 Aug 30;183(2):140-3. doi: 10.1016/j.pscychresns.2010.05.009. Epub 2010 Jul 14.

No volumetric differences in the anterior cingulate of psychopathic individuals.

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  • 1Department of Psychology, University of Pennsylvania, 3809 Walnut Street, Philadelphia, PA 19104, USA.


Functional imaging studies of psychopathy have demonstrated reduced activity in the anterior cingulate, yet it is unclear whether this region is structurally impaired. In this study, we used structural MRI to examine whether volumetric differences exist in the anterior cingulate between psychopathic (n=24) and control (n=24) male participants. We found no group differences in the volume of the anterior cingulate or its dorsal and ventral subregions. Our findings call into question whether the anterior cingulate is impaired in psychopathy, or whether previous findings of reduced activity may result from reduced input from other deficient regions.

Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

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