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Nat Rev Mol Cell Biol. 2010 Aug;11(8):545-55. doi: 10.1038/nrm2938. Epub 2010 Jul 14.

Heat shock factors: integrators of cell stress, development and lifespan.

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  • 1Department of Biosciences, Abo Akademi University, BioCity, 20520 Turku, Finland.

Abstract

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.

PMID:
20628411
[PubMed - indexed for MEDLINE]
PMCID:
PMC3402356
Free PMC Article

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