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Nat Rev Genet. 2010 Aug;11(8):549-58. doi: 10.1038/nrg2847. Epub 2010 Jul 13.

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.

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  • 1Department of Chemistry and Biochemistry, University of Colorado at Boulder, Colorado 80309, USA.


The eukaryotic core promoter recognition complex was generally thought to play an essential but passive role in the regulation of gene expression. However, recent evidence now indicates that core promoter recognition complexes together with 'non-prototypical' subunits may have a vital regulatory function in driving cell-specific programmes of transcription during development. Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions.

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