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Clin Cancer Res. 2010 Jul 15;16(14):3754-9. doi: 10.1158/1078-0432.CCR-10-0439. Epub 2010 Jul 13.

Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

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  • 1Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, University of Edinburgh and MRC Human Genetics Unit, Edinburgh, United Kingdom.

Abstract

PURPOSE:

To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival.

EXPERIMENTAL DESIGN:

To determine whether single-nucleotide polymorphisms tagging these 10 loci influenced all-cause and CRC-specific mortality, we prospectively followed survival outcomes for 2,838 Scottish patients recruited soon after a diagnosis of CRC. Survival analysis was conducted using Cox proportional hazard models adjusted for American Joint Committee on Cancer stage, age, and sex.

RESULTS:

None of the single-nucleotide polymorphisms were found to be statistically significantly associated with all-cause or CRC-specific mortality.

CONCLUSIONS:

We conclude that none of the 10 common genetic variants thus far shown to be associated with CRC risk are associated with survival from CRC.

Copyright 2010 AACR.

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